| Feleipe Franks (ATL) | DNP vs. Tampa | 10 games (1 start); 1 attempt |
| Armon Watts (CHI) | 1 game (0 starts); 47 snaps vs. Minnesota | 17 games (12 starts); 35 tackles (15 solo), 1 sack |
| Brandon Allen (CIN) | DNP vs. Baltimore | 1 game (0 starts); 3-for-3, 22 yards |
| Hjalte Froholdt (CLE) | 1 game (0 starts); 3 snaps vs. Pittsburgh | 17 games (6 starts) |
| Jason Peters (DAL) | 1 game (1 start); 68 snaps vs. Washington | 12 games (1 start) |
| Jerry Jacobs (DET) | 1 game (1 start); 66 snaps vs. Green Bay, 5 solo tackles | 12 games (8 starts); 42 tackles (30 solo), 1 INT, 1 SK |
| Frank Ragnow (DET) | 1 game (1 start); 62 snaps vs. Green Bay | 16 games (16 starts) |
| Dan Skipper (DET) | 1 game (0 starts); 7 snaps vs. Green Bay | 16 games (5 starts) |
| Montaric Brown (JAX) | DNP vs. Tennessee | 7 games (1 start); 6 tackles (4 solo |
| Hunter Henry (NE) | 1 game (1 start); 68 snaps vs. Buffalo, 6 receptions, 42 yards, 7.0 yards per catch | 17 games (14 starts); 41 receptions, 509 yards, 2 TDs, 12.4 yards per catch |
| Deatrich Wise Jr. (NE) | 1 game (1 start); 40 snaps vs. Buffalo, 3 tackles (2 solo), 1 sack | 17 games (16 starts); 59 tackles (28 solo), 7.5 sacks, 3 PDEF, 2 FF |
| Dre Greenlaw (SF) | DNP vs. Arizona | 15 games (15 starts); 127 tackles (64 solo), 6 PDEF, 1 INT, 2 FF, 2 FR |
| Treylon Burks (TEN) | 1 game (1 start); 57 snaps vs. Jacksonville, 4 receptions, 19 yards | 11 games (6 starts); 33 receptions, 444 yards, 1 TD, 13.4 yards per catch, 4 rushing attempts, 47 yards, 11.8 yards per touch |
| Cody Hollister (TEN) | DNP vs. Jacksonville | 11 games (3 starts); 3 receptions, 54 yards, 18 average |
| Kamren Curl (WAS) | DNP vs. Dallas | 12 games (12 starts); 83 tackles (54 solo), 1 sack |
| De’Jon Harris (WAS) | DNP vs. Dallas | 4 games (0 starts) |
| John Ridgeway (WAS) | 1 game (1 start); 13 snaps vs. Dallas, 5 tackles (2 solo) | 15 games (4 starts); 24 tackles (6 solo), 1 FF, 1 PDEF |
| Jonathan Williams (WAS) | 1 game (1 start); 32 snaps vs. Dallas, 14 attempts, 32 yards, 2.3 yards per carry, 2 receptions, 9 receiving yards, 4.5 yards per catch | 13 games (2 starts); 37 rushing attempts, 152 rushing yards, 4.1 yards per carry, 7 receptions, 40 receiving yards, 5.7 yards per catch |