| Feleipe Franks (ATL) | DNP vs. Arizona | 10 games (1 start); 1 attempt |
| Armon Watts (CHI) | 1 game (0 starts); 30 snaps vs. Detroit | 16 games (12 starts); 32 tackles (15 solo), 1 sack |
| Brandon Allen (CIN) | Game postponed vs. Buffalo | 1 game (0 starts); 3-for-3, 22 yards |
| Hjalte Froholdt (CLE) | 1 game (0 starts); 5 snaps vs. Washington | 14 games (6 starts) |
| Jason Peters (DAL) | 1 game (0 starts); 16 snaps | 6 games (0 starts) |
| Jerry Jacobs (DET) | 1 game (1 start); 47 snaps vs. Chicago, 3 tackles (1 solo) | 11 games (7 starts); 37 tackles (25 solo), 1 sack, 1 INT |
| Frank Ragnow (DET) | 1 game (1 start); 64 snaps vs. Chicago | 15 games (15 starts) |
| Dan Skipper (DET) | 1 game (0 starts); 20 snaps vs. Chicago | 15 games (5 starts) |
| Montaric Brown (JAX) | DNP vs. Houston | 7 games (1 start); 6 tackles (4 solo |
| Hunter Henry (NE) | 1 game (1 start); 61 snaps vs. Miami, 5 receptions, 52 yards, 10.4 yards per catch | 16 games (13 starts); 35 receptions, 467 yards, 13.3 average, 2 touchdowns |
| Deatrich Wise Jr. (NE) | 1 game (1 start); 61 snaps vs. Miami, 3 tackles (1 solo) | 16 games (15 starts); 56 tackles (26 solo), 6.5 sacks, 3 PDEF, 2 FF |
| Dre Greenlaw (SF) | 1 game (1 start); 43 snaps vs. Las Vegas, 8 tackles (2 solo) | 15 games (15 starts); 127 tackles (64 solo), 6 PDEF, 1 INT, 2 FF, 2 FR |
| Treylon Burks (TEN) | 1 game (1 start); 47 snaps vs. Dallas, 4 receptions, 66 yards, 16.5 yards per catch, 1 rushing attempt, 20 rushing yards | 10 games (5 starts); 29 receptions, 425 yards, 14.7 average, 1 touchdown, 4 rushing attempts, 47 rushing yards, 11.8 yards per touch |
| Cody Hollister (TEN) | DNP vs. Dallas | 11 games (3 starts); 3 receptions, 54 yards, 18 average |
| Kamren Curl (WAS) | DNP vs. Cleveland | 12 games (12 starts); 83 tackles (54 solo), 1 sack |
| De’Jon Harris (WAS) | 1 game (0 starts); 8 snaps vs. Cleveland | 4 games (0 starts) |
| John Ridgeway (WAS) | 1 game (1 start); 37 snaps vs. Cleveland, 2 tackles (1 solo) | 14 games (3 starts); 19 tackles (4 solo), 1 PDEF, 1 FF |
| Jonathan Williams (WAS) | 1 game (0 starts); 34 snaps vs. Cleveland, 9 attempts, 30 rushing yards, 3.3 yards per carry, 3 receptions, 3 receiving yards | 9 games (0 starts); 11 rushing attempts, 77 yards, 7 average |